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Monday, March 24th 2008

4:05 PM

Transient global amnesia after breathing hyperoxic mixtures

Transient global amnesia after breathing hyperoxic mixtures in otherwise regular dives


Here is an article sent to us by Dr. Howard Homler:

Fabio Spignoa, Massimo De Lucchib, Luca Migliazzia and Leonardo Cocitoc, Corresponding Author Contact Information, E-mail The Corresponding Author
a</sup>Department of Occupational Medicine, University of Genova, Genova, Italy
b</sup>Unit of Hyperbaric Therapy, San Martino Hospital, Genova, Italy
c</sup>Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
Received 5 June 2007;  revised 24 August 2007;  accepted 27 August 2007.  Available online 24 October 2007.

Abstract

The diagnosis of decompression sickness may be difficult, particularly when patients present with atypical clinical manifestations after dives going on uneventfully and with full adherence to safety parameters. The case reports involve two divers who presented with transient global amnesia (TGA) immediately after surfacing from otherwise regular dives during which they had been breathing hyperoxic mixtures (Nitrox). A wide spectrum of symptoms of neural dysfunction following hyperoxic mixtures have been reported, including cases of memory impairment related to previous generalized convulsions. After a review of the literature, however, we found no previous reports of TGA, which is very unlikely to result from an epileptic mechanism, as an adverse effect of breathing hyperoxic mixtures.

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